Polynucleotides - the new buzz word in Injectables:
Polynucleotide (PN) treatments, specifically Polydeoxyribonucleotide (PDRN), have been explored and studied extensively for their potential applications in skin rejuvenation and wound healing. The regenerative properties of nucleotides, which are the building blocks of nucleic acids like DNA help promote tissue repair, stimulate collagen production, and improve skin elasticity.
PDRN is commonly derived from salmon DNA fractions. Utilising highly specialised clinical filtration and ultra-purification process, there is no ‘matter’ remaining, just filtered, ultra purified and sterilised natural DNA fractions. It is so purified even those with allergies to fish are noted to be safe to use polynucleotides, with clinical trials reporting NO allergic reactions to date. We should also note that the salmon are not killed to obtain their DNA.
They have been used extensively in general medicine for over 35 years, with over 100 clinical studies demonstrating the benefits of Polynucleotide treatments for aiding skin health and repair. More recently, they have been utilised in the aesthetic medicine field with impressive results. Studies have shown that by upregulating your body’s natural fibroblast production, it can result in increased collagen (47% in 23 days) and a thicker, healthier epidermis (52% in 23 days).
The use of PDRN in dermatology and aesthetic medicine is associated with its potential to stimulate collagen production, enhance wound healing, and improve the overall quality of the skin. The idea is that by introducing PDRN to the skin, it may support cellular processes that contribute to tissue regeneration and skin rejuvenation.
Here are some potential aspects of polynucleotide treatments for the skin:
Wound Healing and Tissue Repair:
Studies show that PDRN has positive effects on wound healing and tissue repair by promoting cell proliferation and migration. This property can be beneficial for addressing skin damage, including scars and other imperfections.
Anti-Inflammatory Properties:
PDRN has been investigated extensively for its potential anti-inflammatory properties, which can be very beneficial for conditions involving skin inflammation. At the same time, they scavenge up free radicals [unstable molecules which accelerate ageing processes in the skin] and help build up the extra-cellular matrix.
Collagen Stimulation:
Some research has explored the ability of PDRN to stimulate the production of collagen, a key protein that provides structure and firmness to the skin, contributes to skin texture and elasticity. Improved collagen levels can contribute to a more youthful and resilient complexion.
Skin Rejuvenation:
PDRN treatments have been proposed for skin rejuvenation, aiming to improve skin texture, reduce fine lines, and enhance overall skin quality.
Moisturization:
PDRN has moisturizing properties, contributing to improved skin hydration.
When and how often should I have treatment?
Polynucleotides are suitable at any age, at any time of year. I generally recommend them when you are starting to see the visual signs of skin ageing, namely crepey thinning skin which is lacking hydration, and lines starting to settle in.
Whilst there is a benefit to having even one syringe of polynucleotides, I recommend a course of at least 2-3, each spaced 2-4 weeks apart.
Polynucleotides can also be incorporated into other skin booster treatments such as Profhilo and Sunekos, and many more of the treatments I offer including anti wrinkle treatments. At your consultation I will be able to guide you through how and when to introduce a protocol.
When will I see results?
The first signs of improvement often begin around 7-10 days after your first treatment, with the full effects visible at around 3-4 weeks and improving for several months afterwards. The product itself is quickly resorbed, within 2-3 weeks. This is when I normally recommend your second, and subsequent treatments to take place. By doing so, we can maintain continued, active stimulation of fibroblast production, maximising short and long-term results.
How long does the effect last?
Polynucleotides differ from other, hyaluronic-based skin boosters and dermal fillers. Rather than giving skin a surge in collagen and elastin, or ‘plumping’ the skin with carefully placed temporary products, polynucleotides are catalysts in the regeneration of fibroblasts – the main cells within the skin’s structure.
The product itself is absorbed by the body fairly rapidly, having activated new cell production. Of course, we continue to age, but the clock has quite literally been turned back in your treated areas.
I recommend maintaining your treatment result by re treating about 9-12 months after your course.
Are polynucleotides safe?
Polynucleotides are generally very well-tolerated.
The main potential side effects relate to the site of the injection i.e. redness, swelling, bruising. More serious side effects, such as allergic reactions, are exceptionally rare.
Mostly after a treatment you may feel slightly numb (if a numbing agent has been used), and will have little bumps and raised reddish areas on the treated area. In some areas these will be hardly noticeable, whilst in others you may have a little more redness and inflammation at the site of treatment. The small bumps can linger for up to 4-5 days after the treatment for eg in the neck area but in most cases they are discreet and by the next day you are completely back to your normal activities.
Any pre-treatment consultation will fully assess and explain any risks for the individual patient.
What areas can I treat with this treatment?
Because the product comes in differing concentrations, we have products suitable for different skin areas and thicknesses. This makes this product incredibly versatile, as it can be used almost anywhere we have crepey ageing skin.
I particularly love this product for use around the eyes, particularly for patients who aren’t suitable for tear trough filler, or who might have a tendency to go puffy if treated with a hyaluronic-acid based products. They are also fantastic for improving the appearance of undereye dark circles.
Are there any contraindications for the treatment?
People with: circulatory disorders, ongoing dermatitis, diabetes, active herpes, autoimmune disease. may be contraindicated for this treatment. This will be discussed at the consultation stage. These treatments like many are also not appropriate for pregnancy or breastfeeding.
